Current Issue : April - June Volume : 2016 Issue Number : 2 Articles : 4 Articles
Dimenhydrinate is an anti-emetic drug which prevents nausea, vomiting and dizziness. It under goes extensive first pass metabolism and it shows variable absorption from GIT. The aim of the present investigation was to develop bilayer caplet dosage form of dimenhydrinate containing combination of immediate and sustained release layers. Dimenhydrinate bilayer caplets were prepared by wet granulation technique. Prepared granules as well as caplets were evaluated for various in-vitro and in-vivo studies. Bilayer caplets were formulated using hydrophilic polymer i.e. HPMC K 4M and the release sustained for a period of 12 hours. Optimized formulation was subjected for in-vivo studies in rabbits. From this research work it was evident that the developed formulation was able to sustain the drug release....
The design of drug release in modified release multiparticulate solid dosage form is deliberately changed from that of a conventional immediate-release solid dosage form to achieve a desired therapeutic effect by even distribution of multiparticulates in the gastro-intestinal (GI) tract and better patient compliance by less GI irritation and low risk of dose dumping. Modified release multiparticulate dosage forms also offer better flow properties, enhance of drug dissolution and ease of coating. In this invention, modified release multiparticulate dosage form of metoprolol succinate was prepared by wet granulation, extrusion and spheronization, drug layering, sub coating, controlled release coating and spray congealing. These controlled release pellets of metoprolol succinate with other excipients were compressed into a tablet. The above formulation was evaluated for chemical parameters like assay and in-vitro drug release study....
Buccal films for the delivery of promethazine hydrochloride were fabricated using various film forming hydrophilic polymers, namely hydroxypropylmethyl cellulose, hydroxyethyl cellulose, sodium alginate and polyvinyl alcohol either alone or in combination with bioadhesive polymer sodium carboxymethyl cellulose. All the films prepared were smooth, elastic and homogenous in appearance. Various physicochemical parameters like weight uniformity, thickness, surface pH, folding endurance drug content, percentage moisture absorption and loss, tensile strength, swelling index, bioadhesive strength were evaluated. An in-vitro release study was carried out for 4 hours and all formulations obeyed first-order release kinetics. The sodium alginate polymer released maximum drug from the films owing to its erodible nature in presence of dissolution media. And it was concluded that optimum amount of bioadhesive polymer is required in the formulations for proper bioadhesion as well as controlled release from the formulations....
The aim of the present study was to design, develop and evaluate 0.5% w/w oral mucoadhesive gel of antimicrobial tinidazole (TZ) for buccal administration in periodontal disease. 12 gel formulas were developed from carbopol 934P (CB 934P) in combination with/ without poloxamer 407 or cellulose derivative gelling agent (sodium carboxymethylcellulose, hydroxypropylcellulose, hydroxyethylcellulose and hydroxypropylmethylcellulose) in different concentrations. CB 934P concentration was constant as 0.5% at 6 formulas and 1% in the others 6 formulas. The developed formulas were evaluated for various parameters like composition compatibility, gelation temperature, viscosity, spreadability, gel strength, mucoadhesion strength, drug content, dose uniformity and in-vitro release study. All formulas were subjected to freeze thaw cycling and 90 days stability studies. Higher poloxamer concentration was associated with lower gelation temperature. Polymer type and concentration were in a direct proportionality with formulas viscosity, mucoadhesion and gel strength. Some formulas gave burst drug release in which more than 50% of tinidazole released after 15 minutes and 100% released after 45 to 60 minutes. Other formulas were able to provide a prolonged drug release lasted for 8 hours. Gel formulas with 0.5% w/w CB 934P alone or combined with 15% w/w poloxamer 407 or 7.5% w/w hydroxypropylcellulose were not able to pass through freeze thaw cycling or/and 90 days stability studies. Finally, mucoadhesive properties and prolonged release behavior of some formulas overcame the main obstacles of buccal application. Hence, both G5 and G2 formulas were recommended for periodontitis treatment by placement in the periodontal pockets....
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